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Over time, diabetes can lead to blindness, kidney failure, and nerve damage. These types of damage are the result of damage to small vessels, referred to as microvascular disease. Diabetes is also an important factor in accelerating the hardening and narrowing of the arteries (atherosclerosis), leading to strokes, coronary heart disease, and other large blood vessel diseases. This is referred to as macrovascular disease.

Depigmentation of the skin can be caused by a number of local and systemic conditions. The pigment loss can be partial (such as after injury to the skin) or complete (such as from vitiligo). It can be temporary or permanent.

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